- Best friends with Amy Davidson.
- Has a German Shepherd named Duke.
- Her dad Gary is a Oxnard, California, Realtor and her mom Layne is a homemaker.
- Is a big fan of Britney Spears.
- Is six years younger then co-star Amy Davidson_8 Simple Rules… for Dating My Teenage Daughter(2002)_ but she plays the older sister in the series.
- Last name, Cuoco, translates to cook in Italian.
- Ranked as #78 in FHM’s 100 Sexiest Women in the World 2005 special supplement (2005).
- Resides in San Fernando Valley, California.
- Shares a birthday with the following celebrities: Ben Stiller, 24 (2001) star Elisha Cuthbert, singer Clay Aiken, 80s punk rocker Billy Idol and Dick Clark.
- She did 6 Barbie ads when she was younger.
- She loves to bowl.
- Was a nationally ranked amateur tennis player until she switched to acting full time in 2002.
- Was home schooled on the set and earned her High School Diploma at the age of 16.
- Also credited as: Kaley Cuaco
- Has a chihuahua dachshund-mix dog named Petey.